This study (May 2022) demonstrates that chronic supplementation with nicotinamide mononucleotide increases blood levels of nicotinamide adenine dinucleotide (NAD+) and alters muscle function in healthy older men.
Summary of results:
In healthy men over 65, daily supplementation with 250 mg of NMN for 12 weeks more than doubled blood NAD+ levels. This regimen also enhanced walking speed and grip strength in older men. These findings suggest that NMN supplementation may aid in mitigating age-related muscle decline.
Summary of research:
Previous studies in animals have shown that increasing nicotinamide adenine dinucleotide (NAD+) through nicotinamide mononucleotide (NMN), an NAD+ precursor, can reduce age-related conditions. However, there is still limited human data on this topic. We investigated whether chronic oral supplementation of NMN could increase blood NAD+ levels and influence physiological dysfunctions in healthy older participants. In a placebo-controlled, randomized, double-blind, parallel study, older men received 250 mg NMN daily for 6 or 12 weeks. Chronic NMN supplementation was well tolerated and had no significant adverse effects. Metabolomic analysis of whole blood samples showed that oral NMN supplementation significantly increased the concentrations of NAD+ and NAD+ metabolites. While nominal improvements were observed in walking speed and performance in the left grip test, these findings need to be confirmed in larger studies. However, NMN had no significant effect on body composition. This suggests that chronic oral NMN supplementation may be an effective way to prevent age-related muscle dysfunction in humans by increasing NAD+ levels.
