NMN studie: NAD+ wordt verhoogd door NMN

NMN study: NAD+ is increased by NMN

In May 2022, the results of an interesting NMN study were published. It was a multicenter, randomized, double-blind, parallel-design, placebo-controlled study to evaluate the efficacy and safety of Uthever (NMN supplement), an orally administered supplementation, in middle-aged and older adults.

Summary of research findings:

On day 30, serum NAD+/NADH levels increased significantly by 11.3% in the Uthever NMN group, while the placebo group showed no change. By day 60, NAD+/NADH levels had risen by 28% from baseline in the NMN group, compared to only 14.3% in the placebo group. The six-minute walking distance improved by 4.3% in the NMN group on day 20, as opposed to 3.9% in the placebo group. By day 60, the NMN group had further increased their walking distance by 6.5%, while the placebo group remained at a 3.9% increase.

Summary of the research:

Objective: The aim of this study was to investigate the anti-aging effect of NMN and assess its safety in a double-blind, parallel, randomized controlled clinical trial.

Methods: Sixty-six healthy subjects aged between 40 and 65 years participated in the study. They were instructed to take two capsules once daily for 60 days, each capsule containing either 150 mg NMN or starch powder, after breakfast.

Results: On day 30, serum NAD+/NADH levels showed a remarkable increase of 11.3% in the Uthever group, while no change was observed in the placebo group. By day 60, NAD+/NADH levels in the Uthever group had further increased by 38% compared to baseline, whereas it was only 14.3% in the placebo group. The SF 36 scores showed a 6.5% increase in the Uthever group on day 60, compared to only 3.4% in the placebo group. At the end of the study, there was a slight increase of 0.6% in the average HOMA IR Index in the Uthever group, while there was a notable increase of 30.6% in the placebo group compared to baseline.

Conclusion: The results demonstrate that NMN supplementation on days 30 and 60 increased serum NAD+/NADH levels, indicating the potential of Uthever to raise NAD+ levels in cells and thus achieve an anti-aging effect. Additionally, improved insulin sensitivity was associated with anti-aging effects. There were no notable changes in the HOMA score in the Uthever group, while there was a notable increase in the placebo group, highlighting the anti-aging effect of Uthever, as parameters worsened in the absence of NMN supplementation.

Source: https://www.frontiersin.org/articles/10.3389/fragi.2022.851698/full



 

  •  
Back to blog

Order one of our Premium NMN products now.

  • Highest purity & maximum biological uptake

    We opt only for the highest quality supplements, ensuring maximum absorption by the body. For instance, our NMN boasts a purity level of >99.8%.

  • Independently laboratory tested

    All supplements undergo double testing and verification in a laboratory for quality, including in NL(EU) or USA.

  • High-quality production (GMP)

    Our supplements are produced according to strict requirements for good and safe production, adhering to various ISO standards within this framework.

  • Onderzoek: TMG een natuurlijk supplement voor het verlagen van homocysteïne en het bevorderen van hartgezondheid

    Research: TMG a natural supplement for lowering...

    Homocysteine, an amino acid that naturally occurs in the blood, is increasingly being seen as a risk factor for cardiovascular diseases. Elevated levels of homocysteine have been linked to an...

    Research: TMG a natural supplement for lowering...

    Homocysteine, an amino acid that naturally occurs in the blood, is increasingly being seen as a risk factor for cardiovascular diseases. Elevated levels of homocysteine have been linked to an...

  • Onderzoek: het effect van betaïne/TMG op het verminderen van lichaamsvet

    Research: the effect of betaine/TMG on reducing...

    In recent years, the increase in obesity has led to the search for effective interventions to reduce body fat. One of the methods investigated is the use of dietary supplements...

    Research: the effect of betaine/TMG on reducing...

    In recent years, the increase in obesity has led to the search for effective interventions to reduce body fat. One of the methods investigated is the use of dietary supplements...

  • Onderzoek: activatie van SIRT1 door Resveratrol, een grote stap tegen veroudering

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

    Research: activation of SIRT1 by Resveratrol, a...

    Sirtuins, specifically SIRTs, are essential proteins that influence various cellular processes, such as mitochondrial function and genome integrity. In mammals, seven variants of sirtuins (SIRT1-SIRT7) have been identified so far,...

1 of 3