Buy NMN: When is the right time?

Not sure whether this is the right time to buy NMN? You’re hearing more and more about this molecule and its effects on your body. It’s only natural that you want to know when supplements add value for you. In this article, you’ll read everything about timing, how it works in your cells, and what to look out for when buying.

What happens in your body that makes people buy NMN?

Nicotinamide mononucleotide (NMN) is a molecule that occurs naturally in all forms of life. Your body produces this substance itself and uses it in all your cells. NMN is an endogenous intermediate step in the production of NAD⁺ and is biochemically related to vitamin B3 (niacin/nicotinamide). NMN serves as a building block for the production of nicotinamide adenine dinucleotide (NAD+)

What exactly is NAD+? This is a coenzyme that your cells use for metabolic reactions. From around your thirties, NAD+ levels in your body gradually decline. Lower levels of this coenzyme are associated with less efficient energy metabolism. In addition, this coenzyme is a well-known factor in the natural cell cycle and the biological processes that support cell stability. 

When you decide to use an NMN supplement to use, you’re not forcing your body to do anything. You’re simply giving your cells the building block they already know, so they can produce NAD+ themselves. 

When is it a logical time to buy NMN?

There is no fixed rule about when to start with NMN. The choice depends on your personal goals and stage of life.

From a certain age

Most people consider NMN from their thirties or forties. This is the point at which the body’s natural production of NAD+ demonstrably begins to decline. You then choose to support the processes that change during this stage of life. 

When energy levels are reduced

Do you notice that you’re tired more often? Persistent fatigue can be a sign that the energy processes in your cells are running less smoothly. NMN is associated with supporting these cellular processes.

When focusing on longevity

Are you actively working on healthy ageing or biohacking? Then NMN may fit with optimizing your lifestyle. Longevity hacking is about making conscious choices for the long term.

During intense sport or physical exertion

NAD+ is involved in your muscle function and aerobic capacity. Athletes Athletes often show interest in NMN because of the role NAD+ plays in aerobic metabolism and energy management in muscle cells. 

After blood values or a biological age test

Sometimes a test is the trigger. Have you had your metabolic health or biological age tested? The results can be a reason to start targeted supplements.

Benefits of NMN at the right time

If you start with NMN, it may be that you support various biological systems.

• Support for NAD+ production: NMN is a direct precursor of NAD+. Your body efficiently converts this molecule.
• Role in mitochondrial energy: NAD+ is needed for the production of ATP in the mitochondria, the powerhouses of your cells.
• Support for recovery: Scientific research1 focuses on the role of NAD+ as a co-factor for sirtuins, which play an important role in the cell’s internal regulation.
• Healthy aging: Preclinical research suggests that NAD+ levels influence cellular regulation during aging

The scientific research1 of Shin-ichiro Imai in 2014 described how sirtuins are completely dependent on the availability of NAD+. These proteins act as a kind of “guardians” of the cell, directing processes that support cellular stability and energy metabolism. Without enough NAD+, these sirtuins cannot perform their regulatory functions optimally.

Buy NMN preventively, or only once you have symptoms?

There is no universal time when you should buy NMN; it depends on your goals, age, and lifestyle. You can approach NMN in two ways. The preventive approach is popular with users who want to optimize their body before they notice changes. They often start around their thirties.

The reactive approach means you start when you notice your energy or recovery capacity is declining. There is no universally correct time. Your own lifestyle and physical condition determine when buying NMN makes sense for you.

NMN and age: what does research say?

The age-related decline of NAD+ has been demonstrated in both animal studies and human research. Studies2 show that oral intake of NMN effectively increases NAD+ levels in adults. Researchers at Keio University in Japan published a clinical study in 2019 on the safety of NMN. Ten healthy men received a single dose of up to 500 mg. The results showed that the body processes NMN safely, without negative effects on blood pressure or heart rate.

Another study3 from Washington University in 2020 focused on the absorption of the substance. This preclinical study showed that NMN enters the bloodstream very quickly from the intestines. After just a few minutes, the amount of NMN in the blood increased, which shortly thereafter led to higher NAD+ levels in the tissues.

NMN dosage

One jar from Enduravita contains 60 capsules. Each capsule contains 250 mg NMN, giving you enough for 30 to 60 days.

Take 1 to 2 tablets daily. Do this in the morning with breakfast. Do not exceed the stated dose. For optimal results, we recommend using two capsules per day (500 mg total).

When to take NMN?

The timing of intake can affect how you experience the supplement. Although there is no fixed time, many users choose the morning.

Taking it with breakfast supports your natural energy cycle. NAD+ is involved in your circadian rhythm and the production of energy, which makes the start of your day a logical time to take it.

Side effects of NMN

In clinical studies NMN is considered safe at the recommended dosage. If you take too high a dose, you may experience mild side effects that are usually temporary:

• Mild stomach and intestinal discomfort
• Nausea
• Headache

The quality of NMN determines the right time

Timing is only effective if the supplement you buy is high quality. At Enduravita, we apply strict standards:

• Each batch is checked for purity and identity.
• We test for the presence of heavy metals.
• Independent laboratories perform analyses.
• Focuses on high bioavailability by using Uthever NMN

The right time to buy NMN depends on your personal situation. Although the natural decline of NAD+ usually begins around your thirties, your energy needs and focus on longevity determine when you start. By choosing a high-quality supplement based on preclinical research, you support the natural processes in your cells in a safe way.

Do you want to support your cellular energy and recovery with a pure supplement? Then order your NMN capsules at Enduravita.

1Imai, S. I., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology. DOI: 10.1016/j.tcb.2014.04.002

2Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., & Itoh, H. (2020). Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. https://doi.org/10.1507/endocrj.EJ19-0313

3Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Berthelier, V., Scott, F. W., Cano, A., Migaud, M. E., & Imai, S. I. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. https://doi.org/10.1038/s42255-018-0009-4